BPC-157. ... BACKGROUND I often observe positive outcomes with BPC-157 across a broad spectrum of health conditions. Blood nourishes cells. Cells generally die of a few things, and one of the most common ones is hypoxia. As the cell gets closer to death, it will inevitably be more stressed. When cells are stressed, they generally tell the rest of the body that they're injured, and release inflammatory signals. Chronic hypoxia -> chronic inflammation. As you get older, vascular aging occurs and your cells lose nourishment. This tends to create stress and kills you faster. Scientists, trying to test the role of blood vessels in aging, gave mice extra 'VEGF' (vascular endothelial growth factor). The function of this is to grow blood vessels. It extended maximum lifespan in mice by up to 50%. [1] Life-extending therapies generally improve health. These studies aren't "the effect of emergency medicine on 90 year old stroke victims," they're "the effect of modulating blood vessel health on lifespan." They improved blood vessel health, and therefore improved systemic health, and this improved lifespan. How does this tie into BPC-157? BPC-157 grows blood vessels through the same mechansim. [2] Among other things, it activates fibroblasts, which are pro-healing cells. [3] What you end up with is a systemic healing program with a strong, nourishing blood supply. This has been shown in multiple studies to do remarkable things. One example is a somewhat greusome experiment: scientists 'broke' the spine of rats. Over a month, some received BPC, some didn't. By the end of the month, all the BPC treated rats recovered tail function, and all of the control rats did not. [4] ... PROTOCOL BPC-157 might be considered, conservatively, for the following issues: - Lingering injuries - Gut issues - Brain injury recovery - Weak joints - Pinched nerves - Aging It's also good to have on hand in case you sustain a mortal injury, including TBI. You should take it immediately following any life threatening injury, and this is non-negotiable in my mind. Unilaterally, in the literature, animals have better outcomes when they have BPC-157 in their system, the earlier the better. I know of no side effects or interactions. It exists endogenously in your gut, so it actually can be considered a bioidentical peptide. As for how to take it: 1. Injections: - 250-500ug (micrograms) is the general dose. - NEVER get an injectable source unless it says "BPC-157 Acetate." The acetate is crucial. Otherwise you could be injecting toxic TFA salts that remain from an incomplete purification process. - It can be done subcutaneously with an insulin syringe. It doesn't need to be at the site of pain. You can just put it in your belly fat and it'll work. - LimitlessLifeNootropics and Science.bio seem to both be good sources for injectable BPC-157. 2. Oral: - Every study seems to show that oral works. - 500ug/day seems to be good. - BPC-157 Arginate/BPC-157 Arginine salt may work better orally. - InfiniWell sells a BPC-157 with SNAC, which has been used with peptides like Semaglutide or Insulin to facilitate intestinal absorption. It seems to work and not be toxic. This is probably the best brand for efficacy, though the SNAC may dissuade some. The genetically-enhanced mice that lived 50% longer had VEGF turned on for the rest of their lives, starting at middle age. It's not clear if you actually have to cycle BPC-157 or not. It's not a 1:1 to VEGF, despite both enhancing blood vessel growth, because BPC-157 also has widespread cytoprotective effects and fibroblast-activating effects. Still, though, I haven't seen real side effects reported anywhere, ever. If I were young or middle age, I'd cycle it -- I'd just buy a bottle and go through it, and wait until I feel like I need more until I buy more. If I were 90 years old, I'd probably just stay on it for the rest of my life until better anti-aging interventions were available. refs: [1] https://www.science.org/doi/10.1126/science.abc8479?url_ver=Z39.88-2003 [2] https://link.springer.com/article/10.1007/s00109-016-1488-y [3] https://doi.org/10.1016/S0928-4257(97)89480-6 [4] https://www.mdpi.com/1467-3045/44/5/130 - anabology